FORMULATION AND CHARACTERIZATION OF LIPOSPHERES OF TELMISARTAN

Authors

  • Shubham Patel, Ashish Manigauha, Nidhi Singhai Author

Abstract

This study focuses on the formulation and characterization of lipospheres loaded with Telmisartan, a poorly soluble antihypertensive drug. Utilizing the melt dispersion technique, various formulations were developed to optimize the yield and drug entrapment efficiency. The physicochemical properties, including particle size, flow characteristics, and drug release profiles, were evaluated. Formulation F4 achieved the highest percentage yield (84.65%) and drug entrapment efficiency (82.45%). Release studies indicated a controlled release mechanism, with 99.05% of the drug released within 12 hours. The results suggest that Telmisartan-loaded lipospheres could enhance drug bioavailability, making them a promising alternative for effective hypertension management.

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Published

2024-09-23

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Section

Articles

How to Cite

FORMULATION AND CHARACTERIZATION OF LIPOSPHERES OF TELMISARTAN. (2024). CAHIERS MAGELLANES-NS, 6(2), 5352-5359. http://magellanes.com/index.php/CMN/article/view/858