DIMER TEST IN SEVERE VERSUS MILD PREECLAMPSIA

Abstract

Background: D.Dimer, is a by-product of blood clotting, has been linked to pregnancy-associated issues like gestational diabetes, premature rupture of membranes, and preeclampsia.

Aim of the study: To determine the D.Dimer levels in women with severe and mild preeclampsia and to correlate its level with severity of preeclampsia and to find out the cutoff points of D.Dimer for preeclampsia.

Patients and Methods: A hospital-based case-control research was conducted from January 1st to September 1st, 2023, on 150 pregnant women diagnosed with preeclampsia at the Duhok Obstetrics and Gynecology teaching hospital in Kurdistan, Iraq. The study divided the women into three groups: severe, mild, and normotensive, and estimated D.Dimer levels before labor.

Results: There was an escalated of mean D.dimer level of 1389.20±754.6 in the control group to 2097.7±229.59 in mild PE and 5429.52±757.11 in severe PE groups. The mean difference between mean D.dimer levels in severe preeclampsia, mild preecalmpsia and normotensive  groups  were statistically significant. Area under the Curve for the cut-off points for serum D.Dimer level revealed that the D.Dimer had an excellent area under the curve (0.932) which was statistically significant. Cut-off points, sensitivity, specificity, positive predictive value, and negative predictive value for D.Dimer demonstrated that 2500.0 point had the highest sensitivity and specificity to differentiate severe versus mild preeclampsia.

Conclusions: A significant association between pre-eclampsia and high D.Dimer levels in pregnant women may contribute to future risk of VTE