STRUCTURE OF THE SMALL INTESTINE MUCOSA AFTER ACUTE HEMORRHAGIC SHOCK AND REPERFUSION OF THE ISCHEMIC LIMB

Abstract

 The functional system of digestion and absorption, integrated with the immune system of the small intestinal mucosa, regulating the homeostasis of the internal environment of the body in the norm, is disrupted 1 hour after acute hemorrhagic shock, reperfusion of the ischemic limb of rabbits. The structures of enterocytes and microvilli, glycocalyx and supraepithelial layer of mucus are damaged. Their disintegration and inclusion of sIgA in their composition causes the translocation of microorganisms into the small intestinal mucosa. Correction with the antihypoxant succinasol effectively prevents ischemic damage to the intestine and the translocation of microorganisms and their toxins.